Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 118.00 | |
25 mg | In stock | $ 219.00 | |
50 mg | In stock | $ 359.00 | |
100 mg | In stock | $ 578.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. |
Targets&IC50 | Ser166phosphorylation in wild-type human RIP1:2.8 nM (IC50), RIP1:1.3 nM (IC50) |
In vitro | GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells. GSK481 has approximately equivalent RIP1 FP potencies against human and cynomolgus monkey RIP1 but was >100-fold less potent against nonprimate RIP[1]. |
Synonyms | GSK'481 |
Molecular Weight | 377.39 |
Formula | C21H19N3O4 |
CAS No. | 1622849-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL (185.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK481 1622849-58-4 Apoptosis NF-Κb RIP kinase inhibit Inhibitor GSK'481 RIPK Receptor-interacting protein kinases GSK-481 GSK 481 inhibitor