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Galidesivir

Catalog No. T10491   CAS 249503-25-1
Synonyms: BCX4430, Immucillin-A

Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.

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Galidesivir Chemical Structure
Galidesivir, CAS 249503-25-1
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Purity: 99.13%
Purity: 96.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.
Targets&IC50 neutral red uptake assay:24.5 μM (EC50)
In vitro Galidesivir (BCX4430) undergoes phosphorylation by cellular kinases to form a triphosphate that mimics ATP. The monophosphate nucleotide of the drug is then incorporated by viral RNA polymerases into the growing RNA chain, leading to premature chain termination[1].In inhibiting the infection of Vero cells with Yellow Fever Virus (YFV), Galidesivir demonstrates effectiveness. The EC50, as determined by the neutral red uptake assay, is 8.3 μg/ml (24.5 μM)[4].
In vivo Galidesivir (BCX4430) exhibits activity following intramuscular, intraperitoneal, and oral administration in various experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy[1].In a hamster model of Yellow Fever (YF), Galidesivir administered at 4 mg/kg via intraperitoneal injection twice daily for 7 days proves to be effective[3].
Synonyms BCX4430, Immucillin-A
Molecular Weight 265.27
Formula C11H15N5O3
CAS No. 249503-25-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL(188.49 mM), sonification is recommended.

TargetMolReferences and Literature

1. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9(3):220-226. 2. Elfiky AA, et al. ICN-1229, Remdesivir, PSI-7977, Galidesivir, and GS 1278 against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. 3. Julander JG, et al. BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrob Agents Chemother. 2014;58(11):6607-6614. 4. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405.

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Keywords

Galidesivir 249503-25-1 Others BCX-4430 BCX4430 BCX 4430 Immucillin-A inhibitor inhibit

 

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