store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | Inquiry | |
50 mg | 10-14 weeks | Inquiry | |
100 mg | 10-14 weeks | Inquiry |
Description | Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals. |
Targets&IC50 | neutral red uptake assay:24.5 μM (EC50) |
In vitro | Galidesivir (BCX4430) undergoes phosphorylation by cellular kinases to form a triphosphate that mimics ATP. The monophosphate nucleotide of the drug is then incorporated by viral RNA polymerases into the growing RNA chain, leading to premature chain termination[1].In inhibiting the infection of Vero cells with Yellow Fever Virus (YFV), Galidesivir demonstrates effectiveness. The EC50, as determined by the neutral red uptake assay, is 8.3 μg/ml (24.5 μM)[4]. |
In vivo | Galidesivir (BCX4430) exhibits activity following intramuscular, intraperitoneal, and oral administration in various experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy[1].In a hamster model of Yellow Fever (YF), Galidesivir administered at 4 mg/kg via intraperitoneal injection twice daily for 7 days proves to be effective[3]. |
Synonyms | BCX4430, Immucillin-A |
Molecular Weight | 265.27 |
Formula | C11H15N5O3 |
CAS No. | 249503-25-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL(188.49 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Galidesivir 249503-25-1 Others BCX-4430 BCX4430 BCX 4430 Immucillin-A inhibitor inhibit