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Gallic acid

Catalog No. T0877   CAS 149-91-7
Synonyms: Gallic acid, 3,4,5-Trihydroxybenzoic acid, Endogenous Metabolite, Apoptosis, Inhibitor, COX, inhibit, Reactive Oxygen Species, Cyclooxygenase, Ferroptosis, Gallate, Benzoic acid

Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.

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Gallic acid, CAS 149-91-7
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
In vitro Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].
In vivo Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].
Cell Research Cell viability is measured using the MTT assay. PC12 cells are incubated at 37?C with Water2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.(Only for Reference)
Synonyms Gallic acid, 3,4,5-Trihydroxybenzoic acid, Endogenous Metabolite, Apoptosis, Inhibitor, COX, inhibit, Reactive Oxygen Species, Cyclooxygenase, Ferroptosis, Gallate, Benzoic acid
Molecular Weight 170.12
Formula C7H6O5
CAS No. 149-91-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 7 mg/mL (41.15 mM)

Ethanol: 32 mg/mL (188.1 mM)

DMSO: 32 mg/mL (188.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Chen Z, Yuan Y, Yang D, et al. Antiviral activities of Polygonum Perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus. Journal of Medical Virology. 2022 1. Nabavi SF, et al. Arh Hig Rada Toksikol. 2013, 64(4):553-9. 2. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Frontiers in Immunology. 2020 Dec 7;11:580593. doi: 10.3389 2. Kang MK, et al. Ann N Y Acad Sci. 2009, 1171:514-20. 3. Dong Q, Li Y, Liu G, et al. High oxygen treatments enhance the contents of phenolic compound and ganoderic acid, antioxidant and DNA damage protective activities of Ganoderma lingzhi fruiting body. Frontiers in Microbiology. 2019, 10: 2363 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. 4. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling[J]. Frontiers in Immunology. 2020, 11: 3197. 4. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 5. Zhang M, Liu D, Zhang Y Q. Rapid analysis of the bioactive components in Saxifraga stolonifera, an edible and medicinal herb with anti-tumor effects, by HPLC-DAD, ESI/MSn[J]. JOURNAL OF APPLIED BOTANY AND FOOD QUALITY. 2019, 92: 123-129. 5. Zhang M, Liu D, Zhang Y Q. Rapid analysis of the bioactive components in Saxifraga stolonifera, an edible and medicinal herb with anti-tumor effects, by HPLC-DAD, ESI/MSn. JOURNAL OF APPLIED BOTANY AND FOOD QUALITY. 2019, 92: 123-129 6. Dong Q, Li Y, Liu G, et al. High oxygen treatments enhance the contents of phenolic compound and ganoderic acid, antioxidant and DNA damage protective activities of Ganoderma lingzhi fruiting body[J]. Frontiers in Microbiology. 2019, 10: 2363.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Preclinical Compound Library HIF-1 Signaling Pathway Compound Library Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Polyphenolic Natural Product Library Drug-induced Liver Injury (DILI) Compound Library Natural Product Library for HTS

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