Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 58.00 | |
10 mg | In stock | $ 95.00 | |
25 mg | In stock | $ 153.00 | |
50 mg | In stock | $ 252.00 | |
100 mg | In stock | $ 450.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 58.00 |
Description | IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor. |
Targets&IC50 | IDO:75 nM(EC50) |
In vitro | In mice bearing B16F10 tumors, NLG919 significantly enhanced the antitumor response of pmel-1 resting cells to homologous hgp100 peptide and CpG-1826. |
In vivo | NLG919 effectively blocks the IDO-induced suppression of T-cell responses, restoring T-cell activity (ED50=80 nM). In mouse dendritic cells (DCs) expressing IDO from tumor lymph nodes (ED50=120 nM), NLG919 abolishes the IDO-induced inhibition of antigen-specific T-cells (OT-1). |
Synonyms | NLG919, Navoximod, NLG-919 analogue, GDC-0919 |
Molecular Weight | 282.38 |
Formula | C18H22N2O |
CAS No. | 1402836-58-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 26 mg/mL(92.1 mM)
DMSO: 15 mg/mL (53.11 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IDO-IN-7 1402836-58-1 Metabolism Indoleamine 2,3-Dioxygenase (IDO) GDC 0919 NLG 919 NLG919 GDC-0919 analogue GDC0919 Inhibitor IDO IN 7 Navoximod inhibit IDOIN7 NLG-919 analogue NLG-919 GDC-0919 inhibitor