Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 57.00 | |
2 mg | In stock | $ 82.00 | |
5 mg | In stock | $ 131.00 | |
10 mg | In stock | $ 168.00 | |
25 mg | In stock | $ 353.00 | |
50 mg | In stock | $ 526.00 | |
100 mg | In stock | $ 759.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 141.00 |
Description | IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. |
Targets&IC50 | OX2:7.85 (pKi) , OX1:6.29 (pKi) |
In vitro | BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1]. |
In vivo | IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2] |
Molecular Weight | 405.49 |
Formula | C23H27N5O2 |
CAS No. | 1373765-19-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (73.98 mM)
You can also refer to dose conversion for different animals. More
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IPSU 1373765-19-5 GPCR/G Protein Neuroscience OX Receptor inhibit HCRT Receptor Hypocretin Receptor Orexin Receptor (OX Receptor) Inhibitor inhibitor