Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. |
Targets&IC50 | HBx:2 nM(Kd) |
In vitro | IR415, at concentrations ranging from 50 to 200 μM, exhibits a dose-dependent inhibition of the Hepatitis B virus X protein (HBx), achieving its minimal effective concentration at 50 μM in the HepG2/GFP-shRNA line expressing HBx. HBx is identified as a suppressor of the host's defense mechanisms, specifically involved in the RNAi-based silencing of viral genes. |
Molecular Weight | 296.34 |
Formula | C13H14F2N4S |
CAS No. | 452967-14-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (421.81 mM)
You can also refer to dose conversion for different animals. More
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IR415 452967-14-5 Microbiology/Virology HBV Inhibitor inhibit cell HepG2 HBX IR 415 IR-415 replication virus Hepatitis B virus VSR hepatitis B inhibitor