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IXA4

Catalog No. T9349   CAS 1185329-96-7

IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.

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IXA4 Chemical Structure
IXA4, CAS 1185329-96-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 80.00
10 mg In stock $ 128.00
25 mg In stock $ 168.00
50 mg In stock $ 271.00
100 mg In stock $ 435.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 98.69%
Purity: 97.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.
In vitro In other cell lines including Huh7 and SHSY5Y cells, IXA4 selectively upregulated XBP1s mRNA relative to genes regulated by ATF6 (eg BiP) or PERK (eg CHOP). IXA4 reduces Aβ levels by 50% in conditioned medium prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant [1]. IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-associated APP mutants. After 4 h of treatment in HEK293T cells, IXA4 promotes adaptive IRE1/XBP1s signaling, but not RIDD [1]. IXA4 also promotes selective transcriptional remodeling of the ER proteostasis pathway relative to the cytoplasmic or mitochondrial pathway [1].
Molecular Weight 436.5
Formula C24H28N4O4
CAS No. 1185329-96-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (187.857 mM)

TargetMolReferences and Literature

1. Grandjean JMD, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020;16(10):1052-1061.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Cell Cycle Compound Library Endoplasmic Reticulum Stress Compound Library Anti-Cancer Compound Library

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Keywords

IXA4 1185329-96-7 Cell Cycle/Checkpoint IRE1 endoplasmic reticulum (ER) proteostasis UPR protein secretion Inhibitor Inositol requiring enzyme 1 IXA 4 unfolded protein response IXA-4 inhibit inhibitor

 

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