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APY29
Catalog No. T3654Cas No. 1216665-49-4
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
APY29
Catalog No. T3654Cas No. 1216665-49-4
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $36 | In Stock | |
| 5 mg | $59 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $186 | In Stock | |
| 50 mg | $317 | In Stock | |
| 100 mg | $572 | In Stock | |
| 500 mg | $1,190 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | In Stock |
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Purity:98.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
| Targets&IC50 | IRE1α:280 nM |
| In vitro | APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase [1]. |
| Molecular Weight | 332.36 |
| Formula | C17H16N8 |
| Cas No. | 1216665-49-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (37.61 mM), Sonication is recommended.  H2O: Insoluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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