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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $36 | In Stock | |
5 mg | $59 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $186 | In Stock | |
50 mg | $317 | In Stock | |
100 mg | $572 | In Stock | |
500 mg | $1,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $65 | In Stock |
Description | APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
In vitro | APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase [1]. |
Molecular Weight | 332.36 |
Formula | C17H16N8 |
Cas No. | 1216665-49-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 33.24 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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