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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $64 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $239 | In Stock | |
50 mg | $378 | In Stock | |
100 mg | $568 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM). |
In vitro | The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM). |
Molecular Weight | 446.41 |
Formula | C24H29Cl2N3O |
Cas No. | 2121989-91-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 50 mg/mL (112.00 mM) DMSO: 110 mg/mL (246.41 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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