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Ibrolipim

Catalog No. T7832   CAS 133208-93-2
Synonyms: NO-1886

Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.

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Ibrolipim Chemical Structure
Ibrolipim, CAS 133208-93-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 77.00
25 mg In stock $ 117.00
50 mg In stock $ 176.00
100 mg In stock $ 263.00
200 mg In stock $ 396.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.47%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
In vitro Ibrolipim?5 and 50 μmol/L significantly increased cholesterol efflux from THP-1 macrophage-derived foam cells to apoA-I or HDL. Moreover, it upregulated the expression of ABCA1 and ABCG1. In addition, LXRα was also upregulated by the?ibrolipim?treatment. In addition, LXRα small interfering RNA completely abolished the promotion effect that was induced by?ibrolipim[1].
In vivo Ibrolipim (NO-1886; 100 mg/kg; oral administration; daily; for 8 weeks; female Sprague-Dawley rats) treatment decreases accumulation of visceral fat and suppresses the increase in body weight resulting from the ovariectomy. Ibrolipim decreases the respiratory quotient and increases expression of the fatty acid translocase messenger RNA (mRNA) in the liver, soleus muscle, and mesenteric fat. Ibrolipim also increases the expression of fatty acid-binding protein mRNA in the liver and soleus muscle and the expression of the uncoupling protein 3 (UCP3) mRNA in the heart, soleus muscle, and mesenteric fat, but not in the brown adipose tissue[2]
Cell Research Human THP-1 cells pre-incubated with ox-LDL served as foam cell models. Specific mRNA was quantified using real-time RT-PCR and protein expression using Western blotting. Cellular cholesterol handling was studied using cholesterol efflux experiments and high performance liquid chromatography assays[1]
Animal Research Animal Model: Female Sprague-Dawley rats (10-week-old; 200-260 g) with experimental ovariectomy treatment. Dosage: 100 mg/kg ? ? ??. Administration: Oral administration; daily; for 8 weeks[2]
Synonyms NO-1886
Molecular Weight 451.25
Formula C19H20BrN2O4P
CAS No. 133208-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (277.01 mM), sonification is recommended.

TargetMolReferences and Literature

1. Chen SG, et al. Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin. 2010 Oct;31(10):1343-9. 2. Kano S , Doi M . NO-1886 (ibrolipim), a lipoprotein lipase–promoting agent, accelerates the expression of UCP3 messenger RNA and ameliorates obesity in ovariectomized rats[J]. Metabolism-clinical & Experimental, 2006, 55(2):151-158.

Related compound libraries

This product is contained In the following compound libraries:
HIF-1 Signaling Pathway Compound Library Orally Active Compound Library GPCR Compound Library ReFRAME Related Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Amiselimod hydrochloride CYM-5541 S1p receptor agonist 1 SLF1081851 AM095 SLB1122168 formic Spns2-IN-1 Siponimod

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Keywords

Ibrolipim 133208-93-2 GPCR/G Protein LPL Receptor obesity fatty inhibit acid Inhibitor lipoprotein lipase Antihyperlipidemic NO 1886 UCP3 NO1886 LDL-C LXRα HDL-C NO-1886 inhibitor

 

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