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Inarigivir ammonium

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Catalog No. T9518Cas No. 2172788-92-8
Alias SB-9200 ammonium, ORI-9020 ammonium

Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (RIG-I) that activates intracellular innate immunity.

Inarigivir ammonium

Inarigivir ammonium

🥰Excellent
Purity: 99.13%
Catalog No. T9518Alias SB-9200 ammonium, ORI-9020 ammoniumCas No. 2172788-92-8
Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (RIG-I) that activates intracellular innate immunity.
Pack SizePriceAvailabilityQuantity
1 mg$328In Stock
5 mg$689In Stock
10 mg$1,050In Stock
25 mg$1,680In Stock
50 mg$2,380In Stock
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Purity:99.13%
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Product Introduction

Bioactivity
Description
Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (RIG-I) that activates intracellular innate immunity.
In vitro
Inarigivir exhibits activity against HBV (hepatitis B virus) variants, including those resistant to all approved nucleo(s)tide analogues for chronic hepatitis B treatment[1].
In vivo
Administration of 100 mg/kg/day Inarigivir (ip) significantly reduces viral DNA in the liver and shows anti-HBV activity while serum HBV DNA is not reduced. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[2].
AliasSB-9200 ammonium, ORI-9020 ammonium
Chemical Properties
Molecular Weight604.53
FormulaC20H29N8O10PS
Cas No.2172788-92-8
SmilesNC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1.N
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 98 mg/mL (162.11 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6542 mL8.2709 mL16.5418 mL82.7089 mL
5 mM0.3308 mL1.6542 mL3.3084 mL16.5418 mL
10 mM0.1654 mL0.8271 mL1.6542 mL8.2709 mL
20 mM0.0827 mL0.4135 mL0.8271 mL4.1354 mL
50 mM0.0331 mL0.1654 mL0.3308 mL1.6542 mL
100 mM0.0165 mL0.0827 mL0.1654 mL0.8271 mL

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