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Indantadol HCl

Indantadol HCl
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
Catalog No. T27606Cas No. 202914-18-9
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Purity:98.24%
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Indantadol HCl

Purity: 98.24%
Catalog No. T27606Alias V-3381, Indantadol, GT-3381, CNP-3381, CMP-3381, CHF-3381Cas No. 202914-18-9

Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$430In Stock
10 mg$636In Stock
25 mg$987In Stock
50 mg$1,360In Stock
100 mg$1,830In Stock
500 mg$3,680In Stock
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Product Introduction

Bioactivity
Description
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
In vivo
In a human heat-capsaicin-induced pain model, Indantadol HCl at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol HCl undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of Indantadol HCl at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists. Most side effects have been observed to be mild, and include dizziness and asthenia. Indantadol HCl is currently in phase II clinical trials in patients with diabetic peripheral neuropathic pain.[1]
AliasV-3381, Indantadol, GT-3381, CNP-3381, CMP-3381, CHF-3381
Chemical Properties
Molecular Weight226.7
FormulaC11H15ClN2O
Cas No.202914-18-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (220.56 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.4111 mL22.0556 mL44.1112 mL220.5558 mL
5 mM0.8822 mL4.4111 mL8.8222 mL44.1112 mL
10 mM0.4411 mL2.2056 mL4.4111 mL22.0556 mL
20 mM0.2206 mL1.1028 mL2.2056 mL11.0278 mL
50 mM0.0882 mL0.4411 mL0.8822 mL4.4111 mL
100 mM0.0441 mL0.2206 mL0.4411 mL2.2056 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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