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Irisolidone

Catalog No. TN1035 CAS 2345-17-7

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.

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Irisolidone, CAS 2345-17-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 278.00
10 mg	In stock	$ 422.00
25 mg	In stock	$ 688.00
50 mg	In stock	$ 957.00
100 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 283.00

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Purity: 99.46%

Purity: 99.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
In vivo	Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion[2].
Source	Natural Products > Fabaceae > Pueraria

Molecular Weight	314.29
Formula	C17H14O6
CAS No.	2345-17-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.14 mg/mL (10 mM)

References and Literature

1. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Arch. 2018 Jun 30. 2. Geum-Dan, Kang, Sang-Yoon, et al. Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils[J]. Molecular Nutrition & Food Research, 2016.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Anti-Gastroenteritis Natural Product Library Polyphenolic Natural Product Library Anti-Ovarian Cancer Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Immunology/Inflammation Compound Library Anti-Lung Cancer Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Pancreatic Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Irisolidone 2345-17-7 Immunology/Inflammation Membrane transporter/Ion channel NF-Κb Chloride channel NF-κB IL Receptor Chloride Channel Cl? Channels Inhibitor hepatoprotective inhibit VRAC inhibitor

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