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Isoastilbin

Catalog No. TN1772 CAS 54081-48-0

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, Isoastilbin has anti-acne and tyrosinase inhibition properties. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer s disease research

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Isoastilbin, CAS 54081-48-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 590.00
25 mg	In stock	$ 943.00
50 mg	In stock	$ 1,270.00
100 mg	In stock	$ 1,690.00
1 mL * 10 mM (in DMSO)	In stock	$ 467.00

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Purity: 99.95%

Purity: 98.11%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, Isoastilbin has anti-acne and tyrosinase inhibition properties. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer s disease research
Targets&IC50	GTase:54.3 μg/mL (IC50)
In vitro	The crude extracts were assayed for antimicrobial activities against Streptococcus sobrinus and for glucosyltransferase (GTase) inhibition. Fourteen extracts inhibited the growth of S. sobrinus by more than 50% and six extracts inhibited GTase activity by more than 50% at a concentration of 100 μg/ml. Koompassia malaccensis (kempas) extracts showed 90% depression of S. sobrinus growth and 80% inhibition of GTase activity at a concentration of 100 μg/ml. Kempas crude extracts were subjected to column chromatography using Sephadex LH-20 and then preparative high-performance liquid chromatography to isolate four compounds A, B, C, and D. These compounds were identified as taxifolin and the flavanonol rhamnoside isomers neoastilbin, astilbin, and Isoastilbin, respectively, from 1H and 13C nuclear magnetic resonance (NMR) spectra and other two-dimensional NMR techniques (COSY, HMBC, and HMQC). Each compound depressed the growth of S. sobrinus over a concentration range of 9.3242.7 μg/ml and showed GTase inhibitory activity with IC50 values in the range 27.4-57.3 μg/ml[1]
Source	Natural Products > Liliaceae > Smilax

Molecular Weight	450.39
Formula	C21H22O11
CAS No.	54081-48-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (55.51 mM)

References and Literature

1. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extractsJ. Wood Sci., 2009, 55(4):308-13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Miao medicine Compound Library Bioactive Compound Library Oxidation-Reduction Compound Library Polyphenolic Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Covalent Inhibitor Library Natural Product Library for HTS Bioactive Compounds Library Max

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Keywords

Isoastilbin 54081-48-0 Microbiology/Virology Proteases/Proteasome Antibacterial Anti-infection Tyrosinase disease anti-apoptotic glycoside Bacterial antimicrobial Inhibitor Antioxidation inhibit dihydroflavonol neuroprotective Alzheimer's inhibitor

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