Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 82.00 | |
25 mg | In stock | $ 168.00 | |
50 mg | In stock | $ 252.00 | |
100 mg | In stock | $ 378.00 |
Description | 1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2. |
Source |
Synonyms | 6,8-Dimethoxyumbelliferone, Phytodolor |
Molecular Weight | 222.19 |
Formula | C11H10O5 |
CAS No. | 486-21-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL(180 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
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Isofraxidin 486-21-5 Immunology/Inflammation MAPK Neuroscience Proteases/Proteasome COX TLR p38 MAPK MMP ERK 6,8-Dimethoxyumbelliferone Cyclooxygenase inhibit hepatoma Matrix metalloproteinases MD-2 COX-2 invasion TLR4 iNOS ERK1/2 MMP-7 cell Phytodolor Inhibitor Toll-like Receptor (TLR) inhibitor