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Isolinderalactone

Catalog No. T8213 CAS 957-66-4

Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.

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Isolinderalactone, CAS 957-66-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 322.00
25 mg	In stock	$ 539.00
50 mg	In stock	$ 772.00
100 mg	In stock	$ 1,050.00
1 mL * 10 mM (in DMSO)	In stock	$ 182.00

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Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
Targets&IC50	iNOS:0.30 uM
In vitro	Isolinderalactone induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future.

Molecular Weight	244.29
Formula	C15H16O3
CAS No.	957-66-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (92.1 mM)

References and Literature

1. Wong S L , Chang H S , Wang G J , et al. Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.[J]. Journal of Natural Products, 2011, 74(12):2489-96. 2. Meng-Chi, Yen, Ying-Chu, et al. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer.[J]. Oncology Reports, 2016.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Cancer Cell Differentiation Compound Library Bioactive Compounds Library Max JAK-STAT Compound Library Anti-Lung Cancer Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Cancer Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isolinderalactone 957-66-4 Immunology/Inflammation JAK/STAT signaling Stem Cells NOS STAT Survivin VEGFR Vascular endothelial growth factor receptor Inhibitor IAP Bcl-2 Family inhibit inhibitor

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