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JNJ-63533054

JNJ-63533054
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
Catalog No. T3119Cas No. 1802326-66-4
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Purity:99.87%
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JNJ-63533054

Catalog No. T3119Cas No. 1802326-66-4
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$36In Stock
10 mg$55In Stock
25 mg$117In Stock
50 mg$198In Stock
100 mg$297In Stock
200 mg$429In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Product Introduction

Bioactivity
Description
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
Targets&IC50
GPR139:16 Nm(EC50)
In vitro
JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. JNJ-63533054 is found to be clean of any cross reactivity as judged by an external selectivity panel of 50 known GPCRs, ion channels, and transporters as well as our own internal whole cell lead generation biology selectivity panel.
In vivo
JNJ-63533054 is found to cross the blood-brain barrier and have good drug-like properties amenable for oral dosing in rat. JNJ-63533054 exhibits good stability in both human and rat microsomes and high solubility in aqueous media, and no DDI potential was found. JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM).
AliasJNJ 63533054
Chemical Properties
Molecular Weight316.78
FormulaC17H17ClN2O2
Cas No.1802326-66-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (142.05 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1568 mL15.7838 mL31.5676 mL157.8382 mL
5 mM0.6314 mL3.1568 mL6.3135 mL31.5676 mL
10 mM0.3157 mL1.5784 mL3.1568 mL15.7838 mL
20 mM0.1578 mL0.7892 mL1.5784 mL7.8919 mL
50 mM0.0631 mL0.3157 mL0.6314 mL3.1568 mL
100 mM0.0316 mL0.1578 mL0.3157 mL1.5784 mL

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