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K-80003

Catalog No. T11734 CAS 1292821-90-9

Synonyms: TX-803

K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.

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K-80003, CAS 1292821-90-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
In vitro	Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization.
In vivo	K-80003 has high affinity to RXRα but lacks COX inhibitory activity.K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals.

Synonyms	TX-803
Molecular Weight	336.4
Formula	C22H21FO2
CAS No.	1292821-90-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (89.18 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73. 2. Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066.

Related Products

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c-Fms-IN-13 Cerdulatinib hydrochloride Chiauranib AEE788 PLX647 PLX5622 hemifumarate K-80003 c-Fms-IN-2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

K-80003 1292821-90-9 蛋白酪氨酸激酶 c-Fms TX-803 K 80003 K80003 Inhibitor inhibitor inhibit

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