Powder: -20°C for 3 years
In solvent: -80°C for 2 years
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
Description | K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation. |
In vitro | Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. |
In vivo | K-80003 has high affinity to RXRα but lacks COX inhibitory activity.K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. |
Synonyms | TX-803 |
Molecular Weight | 336.4 |
Formula | C22H21FO2 |
CAS No. | 1292821-90-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 30 mg/mL (89.18 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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K-80003 1292821-90-9 蛋白酪氨酸激酶 c-Fms TX-803 K 80003 K80003 Inhibitor inhibitor inhibit