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K00135

Catalog No. T27704 CAS 869650-21-5

Synonyms: K-00135, Imidazol[1,2-b]pyridazine 1, K 00135, IMIDAZOPYRIDAZIN 1

K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.

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K00135, CAS 869650-21-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
2 mg	In stock	$ 293.00
5 mg	In stock	$ 449.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 437.00

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Purity: 97.88%

Biological Description

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Description

K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.

In vitro

K00135 dose-dependently impairs the survival of murine Ba/F3 cells that have been rendered cytokine independent by overexpression of human PIMs. K00135 impairs survival and clonogenic growth of a panel of human acute leukemia cells. Exposure of K00135 significantly suppresses in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells[3].

Synonyms	K-00135, Imidazol[1,2-b]pyridazine 1, K 00135, IMIDAZOPYRIDAZIN 1
Molecular Weight	306.36
Formula	C18H18N4O
CAS No.	869650-21-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.4 mg/mL (14.36 mM)

References and Literature

1. Darby RA, et al. Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors. Cancer Chemother Pharmacol. 2015 Oct;76(4):853-64. 2. Yan B, et al. Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. Gastric Cancer. 2012 Apr;15(2):188-97. 3. Pogacic V, et al. Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res. 2007 Jul 15;67(14):6916-24. 4. Taparowsky EJ, Gerbi SA. Structure of 1.71 lb gm/cm(3) bovine satellite DNA: evolutionary relationship to satellite I. Nucleic Acids Res. 1982 Sep 25;10(18):5503-15.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Bioactive Compound Library Anti-Pancreatic Cancer Compound Library Epigenetics Compound Library Bioactive Compounds Library Max

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M-110 HJ-PI01 XL413 Hispidulin AZD1208 Neoprzewaquinone A XL413 hydrochloride GNE-955

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

K00135 869650-21-5 Chromatin/Epigenetic JAK/STAT signaling Pim K-00135 Imidazol[1,2-b]pyridazine 1 K 00135 IMIDAZOPYRIDAZIN 1 inhibitor inhibit

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