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Kakkalide

Catalog No. TN1829Cas No. 58274-56-9

Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.

Kakkalide

Kakkalide

Purity: 100%
Catalog No. TN1829Cas No. 58274-56-9
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
Pack SizePriceAvailabilityQuantity
1 mg$197In Stock
5 mg$417In Stock
10 mg$622In Stock
25 mg$992In Stock
50 mg$1,330In Stock
100 mg$1,780In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
In vitro
Human umbilical vein endothelial cells (HUVEC) were stimulated with 100 μmol/L palmitate (PA) for 30 min and the effects of 30 min pretreatment with 0.1-10 μmol/L Kakkalide on reactive oxygen species (ROS)-associated inflammation in cells were evaluated by western blot analysis and reverse transcription-polymerase chain reaction. Furthermore, we investigated the biomodulation of insulin signaling by Kakkalide along the insulin receptor substrate (IRS)-1/Akt/endothelial nitric oxide synthase (eNOS) pathway. We also determined the effects of 30 min pretreatment with 0.1-10 μmol/L Kakkalide on insulin-mediated endothelium-dependent vasodilation of rat aorta in vitro following stimulation with 100 μmol/L PA. Kakkalide inhibited ROS overproduction and effectively restored mitochondrial membrane potential, demonstrating its chemoprotection of mitochondrial function. In addition, Kakkalide inhibited ROS-associated inflammation in the endothelium by inhibiting tumor necrosis factor-α± and interleukin-6 production and gene expression, as well as suppressing the phosphorylation of c-Jun N-terminal kinase and IκB kinase β/nuclear factor-κB. Inflammation impaired insulin phosphatidylinositol 3-kinase (PI3K) signaling and reduced insulin-mediated NO production in endothelial cells. Kakkalide facilitated PI3K signaling by positively regulating serine/tyrosine phosphorylation of IRS-1.
Chemical Properties
Molecular Weight608.54
FormulaC28H32O15
Cas No.58274-56-9
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6433 mL8.2164 mL16.4328 mL82.1639 mL
5 mM0.3287 mL1.6433 mL3.2866 mL16.4328 mL
10 mM0.1643 mL0.8216 mL1.6433 mL8.2164 mL

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