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MB-07811

Catalog No. T16018 CAS 852948-13-1

Synonyms: VK-2809

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.

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MB-07811, CAS 852948-13-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 437.00
10 mg	In stock	$ 646.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00

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Purity: 97.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.
In vitro	MB-07811 has a low affinity for thyroid hormone receptors with a Ki of 14.6 μM for TRβ and a Ki of 12.5 μM for TRα[2].
In vivo	In diet-induced obese mice, MB-07811 (0.3-30 mg/kg) decreases cholesterol and triglycerides[2].

Synonyms	VK-2809
Molecular Weight	514.98
Formula	C28H32ClO5P
CAS No.	852948-13-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (87.38 mM)

References and Literature

1. Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. 2. Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5.

Related compound libraries

This product is contained In the following compound libraries：

Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Methimazole 2-Thiouracil Glutaurine aceate TR antagonist 1 AH-3960 CO23 Liothyronine sodium Carbimazole

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MB-07811 852948-13-1 Endocrinology/Hormones Thyroid hormone receptor(THR) MB07811 VK2809 MB 07811 VK-2809 VK 2809 inhibitor inhibit

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