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MID-1

Catalog No. T8773 CAS 312608-54-1

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake

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MID-1, CAS 312608-54-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 672.00
100 mg	In stock	$ 956.00
500 mg	In stock	$ 1,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 185.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	293.3
Formula	C12H11N3O4S
CAS No.	312608-54-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.25 mg/mL (106.55 mM), Sonication is recommended.

References and Literature

1. Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library PPI Inhibitor Library Ubiquitination Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library Metabolism Compound Library Anti-Aging Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MID-1 312608-54-1 Others Tyrosine Kinase/Adaptors IGF-1R inhibit MID 1 Inhibitor MG53 ubiquitination MID1 Insulin Receptor insulin association glucose IRS-1 degradation inhibitor

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