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ML-SA1
🥰Excellent
Catalog No. T23004Cas No. 332382-54-4
Alias Mucolipin synthetic agonist 1
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].
ML-SA1
🥰Excellent
Purity: 99.28%
Catalog No. T23004Alias Mucolipin synthetic agonist 1Cas No. 332382-54-4
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 44 € | In Stock | |
| 10 mg | 70 € | In Stock | |
| 25 mg | 146 € | In Stock | |
| 50 mg | 243 € | In Stock | |
| 100 mg | 364 € | In Stock | |
| 200 mg | 549 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 57 € | In Stock |
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Purity:99.28%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1]. |
| Targets&IC50 | ZIKV:52.99 μM (IC50), DENV-2:8.3 μM (IC50) |
| In vitro | ML-SA1 (25 μM; 0~14 hours; A549 cells) potentially affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows no cytotoxicity at concentrations up to 200 μM. It significantly suppresses DENV2 RNA levels with an IC50 of 8.93 μM[1]. ML-SA1 also reduces ZIKV RNA and protein levels in a dose-dependent manner, with an IC50 of 52.99 μM against ZIKV RNA. As an activator of TRPMLs, ML-SA1 is a potent inhibitor of DENV2 and ZIKV in vitro, promoting lysosomal acidification and protease activity to inhibit viral infection, and can induce autophagy in Huh7 or A549 cells[1]. |
| Alias | Mucolipin synthetic agonist 1 |
| Molecular Weight | 362.42 |
| Formula | C22H22N2O3 |
| Cas No. | 332382-54-4 |
| Smiles | CC1CC(C)(C)N(C(=O)CN2C(=O)C3=CC=CC=C3C2=O)C2=C1C=CC=C2 |
| Relative Density. | 1.226 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 17 mg/mL (46.90 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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