Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 74.00 | |
25 mg | In stock | $ 154.00 | |
50 mg | In stock | $ 256.00 | |
100 mg | In stock | $ 384.00 | |
200 mg | In stock | $ 578.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1]. |
Targets&IC50 | ZIKV:52.99 μM (IC50), DENV2:8.3 μM (IC50) |
In vitro |
ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1]. ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1]. |
Synonyms | Mucolipin synthetic agonist 1 |
Molecular Weight | 362.42 |
Formula | C22H22N2O3 |
CAS No. | 332382-54-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17 mg/mL (46.90 mM)
You can also refer to dose conversion for different animals. More
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ML-SA1 332382-54-4 Membrane transporter/Ion channel Others TRP/TRPV Channel lysosomal ML SA1 Inhibitor inhibit protease Transient receptor potential channels autophagy broad-spectrum selective Mucolipin synthetic agonist 1 acidification Zika MLSA1 ML-SA-1 antiviral TRP Channel virus Dengue inhibitor