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MMAD
MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).
Catalog No. T4677Cas No. 203849-91-6
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Purity:99.91%
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MMAD
Catalog No. T4677Alias Monomethylauristatin D, Demethyldolastatin 10, Monomethyl Dolastatin 10Cas No. 203849-91-6
MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $70 | In Stock | |
| 25 mg | $133 | In Stock | |
| 50 mg | $223 | In Stock | |
| 100 mg | $333 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs). |
| In vitro | MMAD (Monomethyl Dolastatin 10) undergoes a stable oxime-ligation to produce several nearly homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of approximately 2.0. These conjugates exhibit favorable pharmacokinetic properties and potent in vitro cytotoxicity against HER2+ cancer cells. Furthermore, ADCs synthesized using site-specific unnatural amino acids display enhanced in vitro cytotoxicity compared to those prepared through cysteine alkylation after native interchain disulfide reduction. |
| In vivo | The resulting antibody-drug conjugates (ADCs) demonstrated complete tumor regression in rodents and showed an improved toxicology profile in rats. |
| Alias | Monomethylauristatin D, Demethyldolastatin 10, Monomethyl Dolastatin 10 |
| Molecular Weight | 771.06 |
| Formula | C41H66N6O6S |
| Cas No. | 203849-91-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 24.5 mg/mL (31.77 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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