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MRTX-1257

Catalog No. T16143Cas No. 2206736-04-9

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.

MRTX-1257

MRTX-1257

Purity: 99.07%
Catalog No. T16143Cas No. 2206736-04-9
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.
Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
2 mg$82In Stock
5 mg$133In Stock
10 mg$231In Stock
25 mg$391In Stock
50 mg$586In Stock
100 mg$838In Stock
1 mL x 10 mM (in DMSO)$179In Stock
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Purity:99.07%
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Product Introduction

Bioactivity
Description
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.
In vivo
MRTX-1257 shows sustained regression at 3,10, 30, and 100 mg/kg dose groups. MRTX-1257 dosed of 100 mg/kg daily causes complete responses that are maintained >70 days after cessation of treatment. MRTX-1257 (1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg and 100 mg/kg, orally, daily for 30 days) displays rapid tumor growth inhibition at all dose groups in MIA PaCa-2 G12C Xenograft model in mice .
Chemical Properties
Molecular Weight565.71
FormulaC33H39N7O2
Cas No.2206736-04-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 35 mg/mL (61.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7677 mL8.8385 mL17.6769 mL88.3845 mL
5 mM0.3535 mL1.7677 mL3.5354 mL17.6769 mL
10 mM0.1768 mL0.8838 mL1.7677 mL8.8385 mL
20 mM0.0884 mL0.4419 mL0.8838 mL4.4192 mL
50 mM0.0354 mL0.1768 mL0.3535 mL1.7677 mL

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