Shopping Cart

Remove All

Your shopping cart is currently empty

MS049

Select Batch

Purity:98%

Resource Download

COA HNMR

MS049

Catalog No. T4378Cas No. 1502816-23-0

MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$77	In Stock
25 mg	$160	In Stock
50 mg	$298	In Stock
100 mg	$547	In Stock
200 mg	$758	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "MS049"

Product Introduction

Bioactivity

Description	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
In vitro	In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM.
Cell Research	HEK293 cells grown in DMEM supplemented with 10% FBS, penicillin (100 U/mL), and streptomycin (100 μg/mL) were seeded on 96-well plates at density 3000/well and treated with compounds at 0, 1, 10, and 50 μM concentrations for 96 h. The confluency was measured using IncuCyte ZOOM live cell imaging device and analyzed with IncuCyte ZOOM software based on phase contrast images.

Chemical Properties

Molecular Weight	248.36
Formula	C15H24N2O
Cas No.	1502816-23-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (221.45 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0264 mL	20.1321 mL	40.2641 mL	201.3207 mL
5 mM	0.8053 mL	4.0264 mL	8.0528 mL	40.2641 mL
10 mM	0.4026 mL	2.0132 mL	4.0264 mL	20.1321 mL
20 mM	0.2013 mL	1.0066 mL	2.0132 mL	10.0660 mL
50 mM	0.0805 mL	0.4026 mL	0.8053 mL	4.0264 mL
100 mM	0.0403 mL	0.2013 mL	0.4026 mL	2.0132 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc