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MS049

Catalog No. T4378 CAS 1502816-23-0

MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.

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MS049, CAS 1502816-23-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 160.00
50 mg	In stock	$ 298.00
100 mg	In stock	$ 547.00
200 mg	In stock	$ 758.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98%

Biological Description

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Description	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
Targets&IC50	PRMT4:34 nM, PRMT6:43 nM
In vitro	In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM.
Cell Research	HEK293 cells grown in DMEM supplemented with 10% FBS, penicillin (100 U/mL), and streptomycin (100 μg/mL) were seeded on 96-well plates at density 3000/well and treated with compounds at 0, 1, 10, and 50 μM concentrations for 96 h. The confluency was measured using IncuCyte ZOOM live cell imaging device and analyzed with IncuCyte ZOOM software based on phase contrast images.

Molecular Weight	248.36
Formula	C15H24N2O
CAS No.	1502816-23-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (221.45 mM)

References and Literature

1. Shen Y,etal.Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.J Med Chem. 2016 Oct 13;59(19):9124-9139.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Epigenetics Compound Library Bioactive Compound Library Reprogramming Compound Library Stem Cell Differentiation Compound Library Anti-Aging Compound Library NO PAINS Compound Library Histone Modification Compound Library Methylation Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MS049 1502816-23-0 Chromatin/Epigenetic Histone Methyltransferase arginine HEK293 dimethylation MS 049 Inhibitor toxic H4R3me2a inhibit selective epigenetic MS-049 cells modifiers inhibitor

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