Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 397.00 | |
500 mg | In stock | $ 913.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. |
In vivo | In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.?Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.?Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose[1]. |
Molecular Weight | 269.13 |
Formula | C11H10Cl2N4 |
CAS No. | 7761-45-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (14.86 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Metoprine 7761-45-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation Neuroscience Histone Methyltransferase Histamine Receptor Antifolate Inhibitor histamine HMT barrier antitumor N-methyltransferase diaminopyrimidine inhibit BW 197U blood-brain inhibitor