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Miglustat hydrochloride

Catalog No. TQ0155   CAS 210110-90-0
Synonyms: NB-DNJ hydrochloride, N-Butyldeoxynojirimycin hydrochloride, OGT918 hydrochloride

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

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Miglustat hydrochloride Chemical Structure
Miglustat hydrochloride, CAS 210110-90-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 80.00
10 mg In stock $ 143.00
25 mg In stock $ 287.00
50 mg In stock $ 497.00
100 mg In stock $ 723.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 99.61%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.
In vivo Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food[1].
Synonyms NB-DNJ hydrochloride, N-Butyldeoxynojirimycin hydrochloride, OGT918 hydrochloride
Molecular Weight 255.74
Formula C10H22ClNO4
CAS No. 210110-90-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 34 mg/mL (132.95 mM)

DMSO: 60 mg/mL (234.61 mM), sonification is recommended.

TargetMolReferences and Literature

1. van Giersbergen, P.L. and J. Dingemanse, Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. J Clin Pharmacol, 2007. 47(10): p. 1277-82. 2. Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Approved Drug Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library Bioactive Compounds Library Max Clinical Compound Library Orally Active Compound Library Inhibitor Library Bioactive Compound Library

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Keywords

Miglustat hydrochloride 210110-90-0 Metabolism Transferase N-Butyldeoxynojirimycin Hydrochloride N-Butyldeoxynojirimycin NB-DNJ hydrochloride OGT-918 type I gaucher disease Miglustat oral Glucosylceramide Synthase (GCS) OGT918 Miglustat Hydrochloride OGT918 Hydrochloride ceramide glucosyltransferase NB-DNJ Inhibitor inhibit OGT 918 OGT 918 Hydrochloride N-Butyldeoxynojirimycin hydrochloride OGT-918 Hydrochloride OGT918 hydrochloride NB-DNJ Hydrochloride inhibitor

 

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