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Mirodenafil

Catalog No. T16079 CAS 862189-95-5

Synonyms: SK3530

Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mirodenafil, CAS 862189-95-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 44.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 136.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 355.00
500 mg	In stock	$ 842.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

In vitro

The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone [2]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil, in these healthy Korean male volunteers [3].

Synonyms	SK3530
Molecular Weight	531.67
Formula	C26H37N5O5S
CAS No.	862189-95-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (51.72 mM)

References and Literature

1. Paick, J.S., et al., Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction. J Sex Med, 2008. 5(11): p. 2672-80. 2. Kim, B.H., et al., Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea. Clin Ther, 2009. 31(6): p. 1234-43. 3. Shin, K.H., et al., The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study. Clin Ther, 2009. 31(12): p. 3009-20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Human Metabolite Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Mirodenafil 862189-95-5 Metabolism PDE Beta catenin SK-3530 Glucocorticoid Receptor Wnt Apoptosis β-catenin inhibit systemic sclerosis NIH3T3 erectile dysfunction Alzheimer’s disease HT-22 cells SH-SY5Y MRC-5 cells fibrosis SK3530 Inhibitor SK 3530 Phosphodiesterase (PDE) inhibitor

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