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Mitochonic acid 5

Catalog No. T8366   CAS 1354707-41-7
Synonyms: MA-5

Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.

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Mitochonic acid 5 Chemical Structure
Mitochonic acid 5, CAS 1354707-41-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
5 mg In stock $ 97.00
10 mg In stock $ 189.00
25 mg In stock $ 378.00
50 mg In stock $ 568.00
100 mg In stock $ 815.00
1 mL * 10 mM (in DMSO) In stock $ 116.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.
In vitro Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis[1].
Cell Research TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment. Cellular apoptosis was assessed using the MTT and TUNEL assays. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining, ROS flow cytometry analysis, mPTP opening assessment, and immunofluorescence of cyt-c. Mitophagy was examined using western blots and immunofluorescence. The pathways analysis was carried out using western blots and immunofluorescence with a pathway blocker[1].
Synonyms MA-5
Molecular Weight 329.3
Formula C18H13F2NO3
CAS No. 1354707-41-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (288.49 mM)

TargetMolReferences and Literature

1. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14. 2. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Stem Cell Differentiation Compound Library Lipid Metabolism Compound Library Bioactive Compound Library Anti-Aging Compound Library Covalent Inhibitor Library Glycometabolism Compound Library Mitochondria-Targeted Compound Library Cuproptosis Compound Library Metabolism Compound Library

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Keywords

Mitochonic acid 5 1354707-41-7 Metabolism Mitochondrial Metabolism Inhibitor MA 5 Mitochonic acid5 Mitochonic acid-5 MA-5 MA5 inhibit inhibitor

 

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