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Motolimod

Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.

Catalog No. T6898Cas No. 926927-61-9

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Purity:99.27%

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COA HPLC HNMR

Motolimod

Catalog No. T6898Cas No. 926927-61-9

Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$238	In Stock
50 mg	$355	In Stock
100 mg	$507	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Product Introduction

Bioactivity

Description	Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
Targets&IC50	TLR8:100 nM(EC50)
In vitro	Motolimodinduces the production of both TNFα (EC50: 140 nM) and IL-12 (EC50: 120 nM) in PBMCs. In mDCs and monocytes, Motolimodspecifically induces the production of IL-12 and TNFα via NF-κB activation. Motolimodalso induces IFNγ production from NK cells, enhances the lytic function of NK cells and augments ADCC.
In vivo	In ovarian cancer mouse model, TX-2337 augments the effect of pegylated liposomal doxorubicin (PLD).
Kinase Assay	The activity of specific TLR agonists is assessed using the secretory embryonic alkaline phosphatase (SEAP) reporter gene that is linked to NF-κB activation in response to TLR stimulation. Measurement of SEAP activity using the Quanti-blue substrate (InvivoGen) after TLR agonist treatment is carried out.
Cell Research	PBMCs or purified NK cells are prepared as previously described, and the purity of NK cells was approximately 99%. NK cell-mediated cytotoxicity is assessed by Calcein-AM release from labeled target cells. In brief, PBMCs or purified NK cells are cultured for 48 hours in RPMI medium in the presence of VTX-2337 (167 or 500 nmol/L) before incubation with target cells.
Alias	VTX-378, VTX-2337

Chemical Properties

Molecular Weight	458.6
Formula	C₂₈H₃₄N₄O₂
Cas No.	926927-61-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 12 mg/mL (26.2 mM)

DMSO: 51 mg/mL (111.2 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1805 mL	10.9027 mL	21.8055 mL	109.0275 mL
5 mM	0.4361 mL	2.1805 mL	4.3611 mL	21.8055 mL
10 mM	0.2181 mL	1.0903 mL	2.1805 mL	10.9027 mL
20 mM	0.1090 mL	0.5451 mL	1.0903 mL	5.4514 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0436 mL	0.2181 mL	0.4361 mL	2.1805 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0903 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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