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Mycophenolic acid

Catalog No. T1335 CAS 24280-93-1

Synonyms: Mycophenolate, RS-61443

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

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Mycophenolic acid, CAS 24280-93-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 48.00
500 mg	In stock	$ 81.00
1 g	In stock	$ 98.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.77%

Purity: 99.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
In vitro	In murine models, Mycophenolic acid selectively inhibits lymphocyte proliferation, cellular-mediated immune responses, and humoral immune responses.
In vivo	In cultured human, mouse, and rat T lymphocytes and B lymphocytes, Mycophenolic acid inhibits mitogen-induced proliferative responses. Mycophenolic acid can also induce apoptosis in activated CD4+ T cells.

Synonyms	Mycophenolate, RS-61443
Molecular Weight	320.34
Formula	C17H20O6
CAS No.	24280-93-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL (100 mM)

References and Literature

1. Sintchak MD, et al. Cell, 1996, 85(6), 921-930. 2. Eugui EM, et al. Scand J Immunol, 1991, 33(2), 161-173. 3. Anderson D, et al. Mutat Res, 1995, 330(1-2), 115-181. 4. Chapuis AG, et al. Nat Med, 2000, 6(7), 762-768. 5. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 2. Hu M, Wu T, Yang Y, et al. Development and Characterization of a Genetically Stable Infectious Clone for a Genotype I Isolate of Dengue Virus Serotype 1. Viruses. 2022, 14(9): 2073. 3. Hu M, Li W F, Wu T, et al.Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to-4) Using a Newly Developed DENV-3 Infectious Clone and Replicon.Microbiology Spectrum.2023: e00423-23.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Microbial Natural Product Library Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Antiparasitic Natural Product Library RO5 Drug-like Natural Product Library Anti-Tumor Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mycophenolic acid 24280-93-1 Apoptosis Metabolism Microbiology/Virology Dehydrogenase UGT Antifungal Antibacterial Endogenous Metabolite Antibiotic dehydrogenase antitumor IMPDH inhibit Inhibitor Bacterial monophosphate antiviral Mycophenolate RS61443 Fungal RNA influenza RS 61443 viruses RS-61443 Antiangiogenic inosine immunosuppressive inhibitor

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