Powder: -20°C for 3 years
In solvent: -80°C for 2 years
NPS-2143 is a selective potent calcium ion-sensing receptor antagonist.
Description | NPS-2143 is a selective potent calcium ion-sensing receptor antagonist. |
Targets&IC50 | CaSR:43nM/41nM |
In vitro | NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH . The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH. |
In vivo | When infused intravenously in normal rats, NPS 2143 caused a rapid and large increase in plasma levels of PTH. Ca2+ receptor antagonists are termed calcilytics and NPS 2143 is the first substance (either atomic or molecular) shown to possess such activity [1]. When administered together with an antiresorptive agent (estradiol), NPS 2143 causes an increase in trabecular bone volume and bone mineral density in osteopenic rats. |
Synonyms | NPS-2143 HCL |
Molecular Weight | 445.38 |
Formula | C24H25ClN2O2.HCl |
CAS No. | 324523-20-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (112.26 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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NPS-2143 hydrochloride 324523-20-8 GPCR/G Protein CaSR NPS2143 NPS-2143 HCL NPS-2143 NPS 2143 hydrochloride Calcium-sensing receptor inhibit SB-262470A Inhibitor NPS 2143 NPS2143 hydrochloride inhibitor