store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 370.00 | |
5 mg | 35 days | $ 1,380.00 | |
10 mg | 35 days | $ 2,400.00 |
Description | Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM). |
Targets&IC50 | DNMT3B:500 nM |
In vitro | Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[1]. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells[2]. |
Molecular Weight | 302.28 |
Formula | C16H14O6 |
CAS No. | 52934-83-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (314.28 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Nanaomycin A 52934-83-5 Chromatin/Epigenetic Metabolism Microbiology/Virology Parasite DNA Methyltransferase Dehydrogenase DNA MTases silenced antibiotics Inhibitor inhibit falciparum tumor Plasmodium suppressor DNMT3B genes malaria DNMTs inhibitor