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Nitecapone

Catalog No. T7831 CAS 116313-94-1

Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)

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Nitecapone, CAS 116313-94-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
2 mg	In stock	$ 98.00
5 mg	In stock	$ 172.00
10 mg	In stock	$ 288.00
25 mg	In stock	$ 489.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 945.00
1 mL * 5 mM (in DMSO)	In stock	$ 159.00

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Purity: 99%

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Description	Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)
Targets&IC50	S-COMT:300 nM
In vitro	At high micromolar to millimolar concentrations in in vitro research studies, nitecapone is an effective antioxidant, nitric oxide radical scavenger, and iron chelator that can protect cells from lipid peroxidation[1]
In vivo	After single administration, both?nitecapone?and OR-486 reduced mechanical nociceptive thresholds and thermal nociceptive latencies (hot plate test) at 2 and 3 h, regardless of their brain penetration. These effects were still present after chronic treatment with COMT inhibitors for 5 days. Intraplantar injection of carrageenan reduced nociceptive latencies and both COMT inhibitors potentiated this reduction without modifying inflammation. CGP 28014 shortened paw flick latencies. OR-486 did not modify hot plate times in Comt gene deficient mice. Intrathecal?nitecapone?modified neither thermal nor mechanical nociception[2].
Animal Research	Used single and repeated administration of a peripherally restricted, short-acting (nitecapone) and also a centrally acting (3,5-dinitrocatechol, OR-486) COMT inhibitor.?We also tested CGP 28014, an indirect inhibitor of COMT enzyme.?Effects of OR-486 on thermal nociception were also studied in COMT deficient mice.?Effects on spinal pathways were assessed in rats given intrathecal nitecapone[2].

Molecular Weight	265.22
Formula	C12H11NO6
CAS No.	116313-94-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mg/mL (9.43 mM)

References and Literature

1. P.T. Männistö, Kaakkola S . Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors[J]. Pharmacological Reviews, 2000, 51(4):593-628. 2. Inhibitors of catechol‐O‐methyltransferase sensitize mice to pain[J]. British Journal of Pharmacology, 2010, 161(7). 3. Salmela K S , Roine R P , H??K-Nikanne J , et al. Effect of Bismuth and Nitecapone on Acetaldehyde Production by Helicobacter pylori[J]. Scandinavian Journal of Gastroenterology, 1994, 29(6):528-531.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library Antioxidant Compound Library Bioactive Compounds Library Max ReFRAME Related Library Immunology/Inflammation Compound Library Orally Active Compound Library Metabolism Compound Library Bioactive Compound Library

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Serotonin hydrochloride CP-609754 Serotonin OU749 GGTI298 Trifluoroacetate L-739750 2HCl FTI-277 hydrochloride GGTI-2133

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Keywords

Nitecapone 116313-94-1 Metabolism Others Transferase GSH glutathione OR-462 Inhibitor ROS Parkinson COMT OR 462 inhibit OR462 allodynia inhibitor

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