Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related Apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its Antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and Caspase-dependent Apoptosis.
Description | Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis. |
Molecular Weight | 374.38 |
Formula | C20H22O7 |
CAS No. | 34444-37-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Nortrachelogenin 34444-37-6 Apoptosis Cytoskeletal Signaling GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Tyrosine Kinase/Adaptors Antifection COX Caspase Akt HIV Protease IGF-1R NOS NF-κB ROS TNF IL Receptor Prostaglandin Receptor Inhibitor inhibitor inhibit