Powder: -20°C for 3 years | In solvent: -80°C for 1 year
O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 152.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 597.00 | |
25 mg | In stock | $ 953.00 | |
50 mg | In stock | $ 1,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 348.00 |
Description | O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM. |
In vitro | In an in vitro screening of herbal materials for hERG blockers using an automated two-microelectrode voltage clamp assay on Xenopus oocytes, an alkaloid fraction of Nelumbo nucifera Gaertn. (lotus) leaves induced ???50% of hERG current inhibition at 100 μg/mL. Chromatographic separation resulted in the isolation and identification of (-)-asimilobine, 1, nuciferine, 2, O-Nornuciferine, 3, N-nornuciferine, 4, and liensinine, 5. In agreement with in silico predicted ligand-target interactions, 2, 3, and 4 revealed distinct in vitro hERG blockages measured in HEK293 cells with IC50 values of 2.89, 7.91, and 9.75 μM, respectively. |
Source |
Molecular Weight | 281.35 |
Formula | C18H19NO2 |
CAS No. | 3153-55-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (177.71 mM)
You can also refer to dose conversion for different animals. More
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O-Nornuciferine 3153-55-7 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors HER Potassium Channel Inhibitor KcsA inhibit ONornuciferine O Nornuciferine inhibitor