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OTSSP167

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Purity:99.47%

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COA HNMR HPLC

OTSSP167

Catalog No. T1759Cas No. 1431697-89-0

OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$80	In Stock
10 mg	$122	In Stock
25 mg	$197	In Stock
50 mg	$297	In Stock
100 mg	$455	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description	OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
Kinase Assay	in vitro kinase assay: MELK recombinant protein (0.4 μg) is mixed with 5 μg of each substrate in 20 μL of kinase buffer containing 30 mM Tris-HCl (pH), 10 mM DTT, 40 mM NaF, 10 mM MgCl2, 0.1 mM EGTA with 50 μM cold-ATP and 10 Ci of [γ-32P]ATP for 30 min at 30 °C. The reaction is terminated by addition of SDS sample buffer and boiled for 5 min prior to SDS-PAGE. The gel is dried and autoradiographed with intensifying screens at room temperature. OTSSP167 (final concentration of 10 nM) is dissolved in DMSO and added to kinase buffer before the incubation.
Cell Research	Cell Counting Kit-8(Only for Reference)
Alias	MELK inhibitor, OTS167

Chemical Properties

Molecular Weight	487.42
Formula	C25H28Cl2N4O2
Cas No.	1431697-89-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.22 mg/ml (14.82 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1026 mL	0.5129 mL	1.0258 mL	5.1290 mL
50 mM	0.0410 mL	0.2052 mL	0.4103 mL	2.0516 mL
100 mM	0.0205 mL	0.1026 mL	0.2052 mL	1.0258 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc