Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
Pack Size | Availability | Price/USD | Quantity |
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10 mg | 6-8 weeks | $ 608.00 |
Description | OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets. |
Targets&IC50 | Syk:14 nM, Syk:313 nM(EC50) |
In vitro | OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM. OXSI-2 (2 μM) completely shape change and blocks GPVI-mediated dense granule release[2]. OXSI-2 (2 μM) inhibits pyroptotic cell death, inflammasome assembly, caspase-1 activation, IL-1β processing and release and mitochondrial ROS generation[3]. |
Synonyms | OXSI 2, Syk Inhibitor |
Molecular Weight | 353.39 |
Formula | C18H15N3O3S |
CAS No. | 622387-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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OXSI-2 622387-85-3 Angiogenesis Tyrosine Kinase/Adaptors Syk Inhibitor Tyrosine OXSI 2 Potassium Inflammasome PAR Pyroptosis Src kinase Piceatannol Syk Inhibitor Spleen tyrosine kinase inhibit OXSI2 signaling GPVI Inflammation inhibitor