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OXSI-2
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Catalog No. T28281Cas No. 622387-85-3
Alias Syk Inhibitor, OXSI 2
OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
OXSI-2
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Catalog No. T28281Alias Syk Inhibitor, OXSI 2Cas No. 622387-85-3
OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $78 | 35 days | |
| 1 mg | $138 | 35 days | |
| 10 mg | $460 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets. |
| Targets&IC50 | Syk:14 nM, Syk:313 nM(EC50) |
| In vitro | OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM. OXSI-2 (2 μM) completely shape change and blocks GPVI-mediated dense granule release[2]. OXSI-2 (2 μM) inhibits pyroptotic cell death, inflammasome assembly, caspase-1 activation, IL-1β processing and release and mitochondrial ROS generation[3]. |
| Alias | Syk Inhibitor, OXSI 2 |
| Molecular Weight | 353.39 |
| Formula | C18H15N3O3S |
| Cas No. | 622387-85-3 |
| Smiles | C(=C1C=2C(NC1=O)=CC=C(S(N)(=O)=O)C2)C=3C=4C(N(C)C3)=CC=CC4 |
| Relative Density. | 1.48g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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