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Octimibate

Catalog No. T24567Cas No. 89838-96-0
Alias Octimibato

Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascular disease and can be used to study atherosclerosis and thrombosis.

Octimibate

Octimibate

Purity: 99.49%
Catalog No. T24567Alias OctimibatoCas No. 89838-96-0
Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascular disease and can be used to study atherosclerosis and thrombosis.
Pack SizePriceAvailabilityQuantity
1 mg$143In Stock
5 mg$360In Stock
10 mg$530In Stock
25 mg$859In Stock
50 mg$1,180In Stock
100 mg$1,590In Stock
500 mg$3,190In Stock
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Purity:99.49%
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Product Introduction

Bioactivity
Description
Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascular disease and can be used to study atherosclerosis and thrombosis.
In vitro
In suspensions of washed (plasma-free) human platelets, octimibate is a potent inhibitor of aggregation; its IC50 is approx 10 nM for inhibition of aggregation is stimulated by several different agonists, including U46619 and ADP. The inhibitory effects of octimibate on aggregation are not competitive with the stimulatory agonist; the maximal response is suppressed but there is no obvious shift in potency of the agonist. In platelet-rich plasma, octimibate inhibits agonist-stimulated aggregation with an IC50 of approx 200 nM.[2]
Octimibate increases cyclic AMP concentrations in platelets and increases the cyclic AMP-dependent protein kinase activity ratio. Octimibate stimulates adenylyl cyclase activity in human platelet membranes, with an EC50 of 200 nM. The maximal achievable activation of adenylyl cyclase by intimidate is 60% of that obtainable with iloprost. Octimibate has no effect on the cyclic GMP-inhibited phosphodiesterase (phosphodiesterase-ITI), which is the major cyclic AMP-degrading enzyme in human platelets.[2]
AliasOctimibato
Chemical Properties
Molecular Weight454.56
FormulaC29H30N2O3
Cas No.89838-96-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (110 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1999 mL10.9996 mL21.9993 mL109.9965 mL
5 mM0.4400 mL2.1999 mL4.3999 mL21.9993 mL
10 mM0.2200 mL1.1000 mL2.1999 mL10.9996 mL
20 mM0.1100 mL0.5500 mL1.1000 mL5.4998 mL
50 mM0.0440 mL0.2200 mL0.4400 mL2.1999 mL
100 mM0.0220 mL0.1100 mL0.2200 mL1.1000 mL

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