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Oleic acid

Catalog No. T2O2668 CAS 112-80-1

Synonyms: Elaidoic acid, 9Z-Octadecenoic acid, Oleate, 9-Octadecenoic Acid, Glycon Wo, 9-cis-Octadecenoic acid

Oleic acid (Glycon Wo) is a natural product, a common saturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator.

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Oleic acid, CAS 112-80-1

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 40.00
1 mL * 10 mM (in DMSO)	In stock	$ 60.00

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Purity: 99.83%

Purity: 99.33%

Purity: 99%

Purity: 98.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oleic acid (Glycon Wo) is a natural product, a common saturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator.
In vitro	METHODS: Human tumor cells HCG-27, AGS, MDA-MB-231, SGC7901, BGC823 and MCF-7 were treated with Oleic acid (400 μM) for 24-72 h. Cell viability was detected using MTT. RESULTS: Oleic acid stimulated cell viability in HGC-27, MDA-MB-231 cells, and inhibited cell viability in AGS, SGC7901, BGC823 and MCF-7 cells. [1] METHODS: Renal cell carcinoma cells 786-O were treated with Oleic acid (0.05-0.2 mM/L) for 48 h. Apoptosis was detected by Flow Cytometry. RESULTS: Oleic acid retarded apoptosis of 786-O cells in a concentration-dependent manner. [2]
In vivo	METHODS: To detect the antitumor activity in vivo, Oleic acid (10 mg/kg) was administered by gavage to LKB1fl/flp53fl/fl endometrial tumor mouse model five days per week for four weeks. RESULTS: Oleic acid treatment for four weeks significantly inhibited tumor growth by 52.1%.Oleic acid exhibits anti-tumor activity in endometrial cancers, which is dependent on the PTEN/AKT/mTOR signaling pathway. [3] METHODS: To study its role in ischemic injury, Oleic acid (10-30 mg/kg, 5% Tween 20 in sterile saline) was administered intraperitoneally to rodent models of middle cerebral artery occlusion (MCAO), photochromic and four-vessel occlusion (4-VO). RESULTS: Oleic acid administration reduced MCAO-induced infarct volume and functional deficits, photochromic-induced infarct volume, and 4-VO-induced hippocampal neuronal death. [4]

Synonyms	Elaidoic acid, 9Z-Octadecenoic acid, Oleate, 9-Octadecenoic Acid, Glycon Wo, 9-cis-Octadecenoic acid
Molecular Weight	282.46
Formula	C18H34O2
CAS No.	112-80-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (221.27 mM)

References and Literature

1. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330. 2. Liu Z, et al. Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells. Oncol Lett. 2013 Apr;5(4):1395-1399. 3. Deng B, et al. Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer. Cancers (Basel). 2023 Nov 14;15(22):5407. 4. Song J, et al. Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia. Sci Rep. 2019 Jul 24;9(1):10732.

Citations

1. Zhao J, Zeng Z, Chen Y, et al. Lipid droplets are beneficial for rabies virus replication by facilitating viral budding. Journal of Virology. 2021: JVI. 01473-21. 2. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. 3. Chen S, Zhou X, Li W, et al.Development of a novel peptide targeting GPR81 to suppress adipocyte-mediated tumor progression.Biochemical Pharmacology.2023: 115800. 4. Lee S J, Yang H, Kim S C, et al.Ethanol Extract of Radix Asteris Suppresses Osteoclast Differentiation and Alleviates Osteoporosis.International Journal of Molecular Sciences.2023, 24(22): 16526. 5. Fang X X, Wei P, Zhao K, et al.Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.Journal of Cell Biology.2024, 223(4).

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Drug Library Human Endogenous Metabolite Library Drug Repurposing Compound Library Tobacco Monomer Library Miao medicine Compound Library Food Additive Library Mouse Metabolite Compound Library

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Keywords

Oleic acid 112-80-1 Apoptosis Membrane transporter/Ion channel Metabolism Others Endogenous Metabolite ATPase Elaidoic acid Inhibitor 9Z-Octadecenoic acid Oleate 9-Octadecenoic Acid Sodium potassium pump inhibit Na+/K+ ATPase Glycon Wo 9-cis-Octadecenoic acid inhibitor

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