Oleic acid (Glycon Wo) is a natural product, a common monounsaturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator.

METHODS: Human tumor cells HCG-27, AGS, MDA-MB-231, SGC7901, BGC823 and MCF-7 were treated with Oleic acid (400 μM) for 24-72 h. Cell viability was detected using MTT.
RESULTS: Oleic acid stimulated cell viability in HGC-27, MDA-MB-231 cells, and inhibited cell viability in AGS, SGC7901, BGC823 and MCF-7 cells. [1]
METHODS: Renal cell carcinoma cells 786-O were treated with Oleic acid (0.05-0.2 mM/L) for 48 h. Apoptosis was detected by Flow Cytometry.
RESULTS: Oleic acid retarded apoptosis of 786-O cells in a concentration-dependent manner. [2]

METHODS: To detect the antitumor activity in vivo, Oleic acid (10 mg/kg) was administered by gavage to LKB1fl/flp53fl/fl endometrial tumor mouse model five days per week for four weeks.
RESULTS: Oleic acid treatment for four weeks significantly inhibited tumor growth by 52.1%.Oleic acid exhibits anti-tumor activity in endometrial cancers, which is dependent on the PTEN/AKT/mTOR signaling pathway. [3]
METHODS: To study its role in ischemic injury, Oleic acid (10-30 mg/kg, 5% Tween 20 in sterile saline) was administered intraperitoneally to rodent models of middle cerebral artery occlusion (MCAO), photochromic and four-vessel occlusion (4-VO).
RESULTS: Oleic acid administration reduced MCAO-induced infarct volume and functional deficits, photochromic-induced infarct volume, and 4-VO-induced hippocampal neuronal death. [4]