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Ononetin

Catalog No. T23107 CAS 487-49-0

Synonyms: 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).

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Ononetin, CAS 487-49-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 297.00
200 mg	In stock	$ 455.00
500 mg	In stock	$ 736.00

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Purity: 98.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).
Targets&IC50	TRPM3:0.3 μM
In vitro	Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1].
In vivo	Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2].

Synonyms	2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Molecular Weight	258.27
Formula	C15H14O4
CAS No.	487-49-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 30 mg/mL (116.16 mM)

Ethanol: < 30 mg/mL (116.16 mM)

References and Literature

1. I Straub, et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168(8):1835-50. 2. Omar Alkhatib, et al. Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci. 2019 Oct 2;39(40):7840-7852.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Ononetin 487-49-0 Membrane transporter/Ion channel TRP/TRPV Channel Inhibitor Transient receptor potential channels inhibit Ca2+ TRP Channel 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone TRPM3 deoxybenzoin inhibitor

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