Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 478.00 | |
100 mg | In stock | $ 690.00 | |
200 mg | In stock | $ 977.00 | |
500 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis. |
Targets&IC50 | S1P5R:11 nM(EC50), S1P1R:0.41 nM(EC50) |
In vitro | In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation. [1] |
In vivo | In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses Clinicalal symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits Clinicalal and histological disease scores. In a Na?ve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness. [1] |
Synonyms | RPC-1063 |
Molecular Weight | 404.46 |
Formula | C23H24N4O3 |
CAS No. | 1306760-87-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 75 mg/mL (185.4 mM)
Ethanol: 10 mg/mL (24.72 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ozanimod 1306760-87-1 GPCR/G Protein LPL Receptor S1P Receptor RPC1063 RPC 1063 neurosurgery sphingosine 1-phosphate (S1P) inhibit Lysophospholipid Receptor Inhibitor multiple sclerosis (MS) RPC-1063 S1P receptor subtypes 5 (S1P5) S1P receptor subtypes 1 (S1P1) inhibitor