Home Tools
Log in
Cart

Ozanimod

Catalog No. T6923   CAS 1306760-87-1
Synonyms: RPC-1063

Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ozanimod Chemical Structure
Ozanimod, CAS 1306760-87-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 97.00
10 mg In stock $ 147.00
25 mg In stock $ 297.00
50 mg In stock $ 478.00
100 mg In stock $ 690.00
200 mg In stock $ 977.00
500 mg In stock $ 1,450.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.74%
Purity: 99.37%
Purity: 99.25%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis.
Targets&IC50 S1P5R:11 nM(EC50), S1P1R:0.41 nM(EC50)
In vitro In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation. [1]
In vivo In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses Clinicalal symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits Clinicalal and histological disease scores. In a Na?ve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness. [1]
Synonyms RPC-1063
Molecular Weight 404.46
Formula C23H24N4O3
CAS No. 1306760-87-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 75 mg/mL (185.4 mM)

Ethanol: 10 mg/mL (24.72 mM)

TargetMolReferences and Literature

1. Scott FL, et al. Br J Pharmacol. 2016. doi: 10.1111/bph.13476.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Immunology/Inflammation Compound Library Clinical Compound Library FDA-Approved Drug Library Orally Active Compound Library ReFRAME Related Library Approved Drug Library

Related Products

Related compounds with same targets
Ceranib-2 Amiselimod hydrochloride CYM-5541 SKI V PF-543 Citrate PF-543 hydrochloride ML-031 SKI II

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ozanimod 1306760-87-1 GPCR/G Protein LPL Receptor S1P Receptor RPC1063 RPC 1063 neurosurgery sphingosine 1-phosphate (S1P) inhibit Lysophospholipid Receptor Inhibitor multiple sclerosis (MS) RPC-1063 S1P receptor subtypes 5 (S1P5) S1P receptor subtypes 1 (S1P1) inhibitor

 

TargetMol