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PD-118057
🥰Excellent
Catalog No. T16444Cas No. 313674-97-4
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.
PD-118057
🥰Excellent
Purity: 99.16%
Catalog No. T16444Cas No. 313674-97-4
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $628 | In Stock | |
| 50 mg | $997 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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Purity:99.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure. |
| In vitro | PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in acutely isolated guinea pig ventricular cardiomyocytes.[1][2] At 10 μM, PD-118057 counteracts the current inhibition caused by Dof and Mox, preserves the unaltered 'hump' shape of the IKr current, and shows only a marginal increase in the maximum value of the suppressed current.[2] |
| Molecular Weight | 386.27 |
| Formula | C21H17Cl2NO2 |
| Cas No. | 313674-97-4 |
| Smiles | OC(=O)c1ccccc1Nc1ccc(CCc2ccc(Cl)c(Cl)c2)cc1 |
| Relative Density. | 1.353 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (233.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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