Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2. |
Targets&IC50 | DGAT-2:14 nM |
In vivo | PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1]. |
Animal Research | PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1]. |
Molecular Weight | 536.05 |
Formula | C23H30ClN7O4S |
CAS No. | 1469284-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 249 mg/mL (464.50 mM), Sonification is recommended.
H2O: 99 mg/mL (184.68 mM)
You can also refer to dose conversion for different animals. More
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PF-06424439 methanesulfonate 1469284-79-4 Metabolism Transferase Acyltransferase acyl-CoA:cholesterol acyltransferase Inhibitor mono- acylglycerol acyltransferase PF-06424439 PF 06424439 methanesulfonate inhibit Diacylglycerol acyltransferase PF06424439 Diglyceride acyltransferase PF06424439 methanesulfonate PF 06424439 inhibitor