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PF-06873600

Catalog No. T8463   CAS 2185857-97-8

PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.

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PF-06873600 Chemical Structure
PF-06873600, CAS 2185857-97-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 113.00
5 mg In stock $ 282.00
10 mg In stock $ 448.00
25 mg In stock $ 847.00
50 mg In stock $ 1,130.00
100 mg In stock $ 1,530.00
500 mg In stock $ 2,970.00
1 mL * 10 mM (in DMSO) In stock $ 349.00
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Purity: 99.36%
Purity: 98.97%
Purity: 98.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.
Targets&IC50 CDK4:0.13 nM (Ki), CDK2:0.09 nM (Ki), CDK6:0.16 nM (Ki)
In vitro PF-06873600 selectively targets, binds to and inhibits the activity of CDKs.?Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation.?CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells.
Molecular Weight 471.52
Formula C20H27F2N5O4S
CAS No. 2185857-97-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (176.73 mM), sonification is recommended.

TargetMolReferences and Literature

1. NCI Drug Dictionary

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Pancreatic Cancer Compound Library Orally Active Compound Library Anti-Breast Cancer Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library

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Keywords

PF-06873600 2185857-97-8 Cell Cycle/Checkpoint CDK PF 06873600 PF06873600 inhibitor inhibit

 

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