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PF-06952229

Catalog No. T12433   CAS 1801333-55-0
Synonyms: PF06952229

PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PF-06952229 Chemical Structure
PF-06952229, CAS 1801333-55-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 116.00
5 mg In stock $ 289.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
100 mg In stock $ 1,520.00
500 mg In stock $ 2,970.00
1 mL * 10 mM (in DMSO) In stock $ 318.00
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Purity: 99.45%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
Targets&IC50 transforming growth factor-beta receptor 1:
In vivo In MCF-7 ER+ HER2-xenograft breast cancer tumor model, PF-06952229 (30 mg/kg; gavage) combines with Palbociclib results in an improved inhibition of pSMAD2 and a significant increase in survival[1].
Synonyms PF06952229
Molecular Weight 458.91
Formula C23H24ClFN4O3
CAS No. 1801333-55-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (87.2 mM), sonification is recommended.

TargetMolReferences and Literature

1. Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.

Related compound libraries

This product is contained In the following compound libraries:
TGF-beta/Smad Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Prostate Cancer Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Anti-Ovarian Cancer Compound Library Inhibitor Library

Related Products

Related compounds with same targets
Hydroxysafflor yellow A 3,7-DMF Nisevokitug Pentabromophenol Myristoyl tetrapeptide-12 SB-431542 LDN-193189 2HCl SD-208

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Keywords

PF-06952229 1801333-55-0 Stem Cells TGF-beta/Smad PF06952229 PF 06952229 inhibitor inhibit

 

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