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PF-AKT400

Catalog No. T5508 CAS 1004990-28-6

Synonyms: AKT protein kinase inhibitor

PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PF-AKT400, CAS 1004990-28-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 96.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 343.00
25 mg	In stock	$ 579.00
50 mg	In stock	$ 829.00
100 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 263.00

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Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.
Targets&IC50	PKA:450 nM , PKBα:0.5 nM

Synonyms	AKT protein kinase inhibitor
Molecular Weight	400.43
Formula	C20H22F2N6O
CAS No.	1004990-28-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (224.76 mM)

References and Literature

1. Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53(12):4615-4622. 2. Chen SF, et al. Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19(11):5097-5112.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library HIF-1 Signaling Pathway Compound Library Antidepressant Compound Library Reprogramming Compound Library Neuronal Differentiation Compound Library Anti-Ovarian Cancer Compound Library Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Aging Compound Library Anti-Prostate Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-AKT400 1004990-28-6 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PF-AKT-400 Protein kinase B inhibit PKB PF AKT400 PF-AKT 400 Inhibitor PFAKT400 AKT protein kinase inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.