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PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $38 | In Stock | |
25 mg | $77 | In Stock | |
50 mg | $128 | In Stock | |
100 mg | $207 | In Stock | |
200 mg | $297 | In Stock | |
1 mL x 10 mM (in DMSO) | $36 | In Stock |
Description | PQM130 is a neuroprotective compound ,and is a potential anti-AD drug. |
In vitro | PQM130 had already shown anti-inflammatory activity in different in vivo models and neuroprotective activity in human neuronal cells. |
In vivo | The intracerebroventricular (i.c.v.) injection of AβO in mice caused the increase of memory impairment, oxidative stress, neurodegeneration, and neuroinflammation.?Instead, PQM130 (0.5-1 mg/kg) treatment after the i.c.v. AβO injection reduced oxidative damage and neuroinflammation and induced cell survival and protein synthesis through the modulation of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinases (ERK1/2).?Moreover, PQM130 increased brain plasticity and protected mice against the decline in spatial cognition.?PQM130 modulated different pathways compared to donepezil, and it is much more effective in counteracting AβO damage. |
Molecular Weight | 381.46 |
Formula | C23H27NO4 |
Cas No. | 2089415-51-8 |
Smiles | COc1cc(\C=C\C(=O)OCC2CCN(Cc3ccccc3)CC2)ccc1O |
Relative Density. | 1.174 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.5 mg/mL (14.42 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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