Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 298.00 | |
5 mg | In stock | $ 622.00 | |
10 mg | In stock | $ 997.00 | |
25 mg | In stock | $ 1,530.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 713.00 |
Description | PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity. |
Targets&IC50 | LOXL2:8.4 (pki), LOXL2:83 nM (ki), LOXL:5.8 (pki) |
In vitro | PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8)[1]. PXS-5120A inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, collagen oxidation assay, recombinant human LOXL3 and recombinant human LOXL4(IC50s of 5 nM, 9 nM, 6 nM, 6 nM, 13 nM, 16 nM and 280 nM, respectively)[1]. |
In vivo | In mice, PXS-5129A is readily absorbed following oral gavage, and rapidly hydrolyzed to release PXS-5120 (free base) in vivo, affording plasma concentrations well above the LOXL2 IC50 (6 nM) for a prolonged period (>6 h), while remaining well below the IC50 for LOX throughout[1]. |
Molecular Weight | 481.97 |
Formula | C22H25ClFN3O4S |
CAS No. | 2125955-70-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (103.74 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PXS-5120A 2125955-70-4 Neuroscience Others Monoamine Oxidase inhibit MAO Inhibitor PXS5120A PXS 5120A inhibitor